SS-31 is a first-in-class, cell-permeable synthetic tetrapeptide that belongs to the Szeto-Schiller (SS) family of peptides. It is uniquely designed to target the mitochondria, specifically by binding to cardiolipin, a phospholipid found exclusively in the inner mitochondrial membrane. Unlike traditional antioxidants that scavenge free radicals after they are formed, SS-31 research focuses on its ability to prevent the formation of reactive oxygen species (ROS) by optimizing the electron transport chain (ETC). By the year 2026, it has become a cornerstone of mitochondrial medicine research, explored for its potential to “re-energize” aging or damaged cells.
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