Broad-Spectrum Antimicrobial Activity: Investigating the peptide’s electrostatic interaction with, and disruption of, negatively charged bacterial, viral, and fungal cell membranes.
Immunomodulation & Chemotaxis: Evaluating how LL-37 functions as an alarmin, modulating the innate immune response and recruiting key inflammatory cells like neutrophils and T-lymphocytes.
Wound Re-epithelialization & Tissue Repair: Assessing the peptide’s capacity to stimulate keratinocyte migration, accelerate vascularization (angiogenesis), and promote wound-healing models.
Biofilm Disruption & Eradication: Probing the mechanisms by which the peptide prevents bacterial attachment and degrades established pre-formed biofilms of resistant pathogens like Pseudomonas aeruginosa.
Autoimmune and Chronic Inflammatory Cascades: Studying the peptide’s binding affinity to self-DNA/RNA and its downstream role in activating plasmacytoid dendritic cells in disease models like psoriasis.
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